%0 Journal Article %J Nature genetics %D 2011 %T The genome of Theobroma cacao. %A Argout, Xavier %A Salse, Jerome %A Aury, Jean-Marc %A Guiltinan, Mark J %A Droc, Gaetan %A Gouzy, Jerome %A Allegre, Mathilde %A Chaparro, Cristian %A Legavre, Thierry %A Maximova, Siela N %A Abrouk, Michael %A Murat, Florent %A Fouet, Olivier %A Poulain, Julie %A Ruiz, Manuel %A Roguet, Yolande %A Rodier-Goud, Maguy %A Barbosa-Neto, Jose Fernandes %A Sabot, Francois %A Kudrna, Dave %A Ammiraju, Jetty Siva S %A Schuster, Stephan C %A Carlson, John E %A Sallet, Erika %A Schiex, Thomas %A Dievart, Anne %A Kramer, Melissa %A Gelley, Laura %A Shi, Zi %A Bérard, Aurélie %A Viot, Christopher %A Boccara, Michel %A Risterucci, Ange Marie %A Valentin Guignon %A Sabau, Xavier %A Axtell, Michael J %A Ma, Zhaorong %A Zhang, Yufan %A Brown, Spencer %A Bourge, Mickael %A Golser, Wolfgang %A Song, Xiang %A Clement, Didier %A Rivallan, Ronan %A Tahi, Mathias %A Akaza, Joseph Moroh %A Pitollat, Bertrand %A Gramacho, Karina %A D'Hont, Angélique %A Brunel, Dominique %A Infante, Diogenes %A Kebe, Ismael %A Costet, Pierre %A Wing, Rod %A McCombie, W Richard %A Guiderdoni, Emmanuel %A Quetier, Francis %A Panaud, Olivier %A Wincker, Patrick %A Bocs, Stephanie %A Lanaud, Claire %K Cacao %K Cell Nucleus %K DNA %K DNA Transposable Elements %K Evolution, Molecular %K Gene Expression Regulation, Plant %K Genes, Plant %K Genome, Plant %K Genotype %K Homozygote %K In Situ Hybridization %K Models, Genetic %K Quantitative Trait Loci %N 2 %P 101-8 %R 10.1038/ng.736 %V 43 %X We sequenced and assembled the draft genome of Theobroma cacao, an economically important tropical-fruit tree crop that is the source of chocolate. This assembly corresponds to 76% of the estimated genome size and contains almost all previously described genes, with 82% of these genes anchored on the 10 T. cacao chromosomes. Analysis of this sequence information highlighted specific expansion of some gene families during evolution, for example, flavonoid-related genes. It also provides a major source of candidate genes for T. cacao improvement. Based on the inferred paleohistory of the T. cacao genome, we propose an evolutionary scenario whereby the ten T. cacao chromosomes were shaped from an ancestor through eleven chromosome fusions. %8 2011 Feb